・↑について、ファイザー社の取締役 Gottlieb 氏談 「最も重要な点は、症状の重さと脳細胞の死滅に関係がない事だ。重症者が軽症者よりひどい脳の状態を示すわけじゃない。」 動画"The final point is that the um the loss of the tissue didn't correlate with the symptom severity. So it was pretty uniform across the patient population, patients who were more sick and hospitalized didn't seem to be any worse off than patients had milder symptoms." https://www.cnbc.com/2021/06/17/new-covid-study-hints-at-long-term-loss-of-brain-tissue-dr-scott-gottlieb-warns.html
肺への感染は速く起こって速く終わる 脳へのダメージは、よりゆっくり起こり、「回復した」と思われる後も長くウイルスが脳に残存する可能性もある。 それで、脳はCovidに対抗するために肺とは異なり、TLR3という細胞死を起こす物質を分泌するのが大問題。 https://www.clinicaltrialsarena.com/comment/covid-19-brain-damage-dementia-risk/ A team of researchers looking at the brains of deceased Covid-19 patients found that the virus can remain in the brain after death.
Infected brain organoids, on the other hand, upped their production of other molecules, such as TLR3, a member of the toll-like receptor family that plays a fundamental role in pathogen recognition and activation of innate immunity. (〜略) those molecules can also aid in programmed cell death. Rana’s team previously saw a similar brain cell response to Zika virus, an infection known to stunt neonatal brain development.
